The existing approach to ransomware protection involves detecting malicious software through behavior patterns or signatures and then responding to it. However, this approach fails to proactively prevent ransomware attacks on enterprise infrastructure. To effectively combat malware, it is essential to adopt a zero-trust policy for core systems, permitting only approved software that is cryptographically signed and implementing application whitelisting on the operating system. The use case document offers insights on digital signature-based application whitelisting and its efficacy in preventing ransomware attacks.